Elisabeth of France (1602 - 1644). Elisabeth of France or Isabel of Bourbon was Queen Consort of Spain and Portugal as the first spouse of King Philip IV of Spain. She served as regent of Spain during the Catalan Revolt in 1640-42 and 1643-44. She was the eldest daughter of King Henry IV of France and his second spouse Marie de' Medici. Élisabeth, Madame Royale, was born at the Château de Fontainebleau on 22 November 1602; reportedly her mother showed a cruel indifference to her, because she had believed the prophecy of a nun who assured her that she would give birth to three consecutive sons. Shortly after her birth, she was betrothed with Philip Emmanuel, Prince of Piedmont, eldest son and heir of Charles Emmanuel I, Duke of Savoy, by Catherine Michelle, a daughter of King Philip II of Spain. Philip Emmanuel died in 1605. As a daughter of the King of France, she was born a Fille de France. As the eldest daughter of the king, she was known at court by the traditional honorific of Madame Royale. The early years of Madame Royale were spent under the supervision of the royal governess Françoise de Montglat at the Château de Saint-Germain-en-Laye, a quiet place away from the Parisian court in which she shared education and games with her legitimate siblings and the bastard children that her father had from his constant love affairs. When King Henry IV was assassinated outside the Palais du Louvre in Paris on 14 May 1610, her brother the Dauphin succeeded him to the throne as King Louis XIII of France under the Regency of their mother Marie de' Medici. When Elisabeth was ten years old, in 1612, negotiations were begun for a double marriage between the royal families of France and Spain; Elisabeth would marry the Prince of Asturias and her brother Louis the Spanish Infanta Anne. After her proxy marriage to the Prince of Asturias and Louis's proxy marriage to the Infanta Anne, Elisabeth and her brother met their respective spouses for the first time on 25 November 1615 on the Pheasant Island in the river Bidassoa that divides France and Spain between the French city of Hendaye and the Spanish city of Fuenterrabía. This was the last time Louis would see his sister. In Spain, Elisabeth's French name took on the Spanish form of Isabel. The religious ceremony took place in the Saint Mary Cathedral in Burgos. At the time of her marriage, the thirteen-year-old Isabel became the new Princess of Asturias. This marriage followed a tradition of cementing military and political alliances between the Catholic powers of France and Spain with royal marriages. The tradition went back to 1559 with the marriage of King Philip II of Spain with the French princess Elisabeth of Valois, the daughter of King Henry II of France, as part of the Peace of Cateau-Cambrésis. The Exchange of the Princesses at the Spanish Border was painted by Peter Paul Rubens as part of his Marie de' Medici cycle. In 1621, by the time of the birth of the couple's first child, the couple had ascended to the throne of Spain upon the death of Philip III of Spain. The new queen of Spain was aware that her husband had mistresses Elisabeth herself was the subject of rumors about her relations with the noted poet Peralta, who was her gentleman-in-waiting. On 14 May 1622, a fire broke out while the Peralta masque La Gloria de Niquea was being acted before the court. Peralta carried the queen to a place of safety, which caused suspicion about their relationship to deepen. Peralta neglected a significant warning that his life was in peril, and he was murdered as he stepped out of his coach. The responsibility for his death was divided between Philip IV and Olivares. Elisabeth's last child, Infanta Maria Theresa of Spain, would later become queen of France as the wife of her nephew, the future Louis XIV. Unlike her husband and sister-in-law, she would not see the wedding that cemented the peace between her homeland and adopted country, Spain; the countries would be at war until 1659.