Isabella of Portugal. Isabella of Portugal was Holy Roman Empress and Queen of Spain, Germany, Italy, Naples and Sicily and Duchess of Burgundy by her marriage to Emperor Charles V. Married to Charles V from 1526 to her death in 1539, she was Queen regent of Spain during the absences of her husband during 1529-1533, 1535-1536 and 1538-1539.
   Isabella was the granddaughter of the Catholic Monarchs, Isabella I of Castile and Ferdinand II of Aragon. Throughout her life, many compared her to her grandmother for her character and her determination in politics.
   A woman of great beauty and intelligence, Isabella was undoubtedly the Spanish soul of Charles V who, because of his travels in Europe, spent little time in Spain due to political affairs abroad. It was thanks to the governorships of Empress Isabella that Spain was able to remain independent of imperial policies.
   Isabella was the second child and eldest daughter of King Manuel I of Portugal and his second wife Maria of Aragon. She was named after her maternal grandmother and her aunt Isabella, who had been her father's first wife.
   Isabella was second-in-line to the throne until the birth of her brother Luis in 1506. However, as the oldest daughter of Manuel I of Portugal, she was a rather attractive candidate for marriage. Isabella spent a happy childhood in the company of her parents and siblings. She was educated under the supervision of her gover
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