Madonna and Child with Saints John Baptist and Sebastian (1493). Tempera on panel. 178 x 164. Madonna with Child Enthroned between Saints John the Baptist and Sebastian is a painting by the Italian Renaissance artist Pietro Perugino, executed in 1493, and housed in the Uffizi Gallery, Florence. The work was commissioned by Cornelia Salviati, widow of Venetian merchant Giovanni Martini, and his son Roberto, for the chapel of the convent of San Domenico, Fiesole, which had been perhaps restored by Giuliano da Sangallo a few years before. In 1493 Perugino had married Chiara Fancelli, the daughter of architect Luca Fancelli: the face of the Madonna is a portrait of her. In 1786 the panel was acquired for 1000 Italian scudi by Peter Leopold, Grand Duke of Tuscany, becoming part of the future Uffizi Gallery. The original chapel was redecorated by a painting by Lorenzo di Credi; the one now in the church is a copy by Garibaldo Ceccarelli. It was restored in 1995. The background, this time featuring two bays, is one of the many porticoes painted by Perugino in the 1480s and 1490s.